Topography of small vessel cerebrovascular disease differentially impacts cognitive domains across cognitive syndromes.

ABSTRACT:

Introduction

Dementia in Asia, presents distinct neuropathological features, with White Matter Hyperintensities (WMH) emerging as critical indicators of small vessel disease. WMH, classified into Deep White Matter Hyperintensities (DWMH), Periventricular Hyperintensities (PVH), and Fazekas-Total, exhibit high prevalence in Asian populations. Although WMH are prevalent and recognized indicators of small vessel disease, the domain-specific cognitive impact of WMH location remains unclear. We hypothesized that examining both cognitively normal (CN) and mild cognitive impairment (MCI) groups separately would clarify whether WMH topography exerts distinct effects at different stages of cognitive decline.

Methods

430 participants were recruited, and a cross-sectional analysis perf

SUBMITTER: Wang JDJ 

PROVIDER: S-EPMC12705179 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature