Comparison of Short-term and Standard Duration Dual Antiplatelet Therapy in Elderly Patients: A Pooled Analysis of Five Korean Randomized Clinical Trials.

ABSTRACT:

Backgrounds and objectives

Data on the optimal duration of dual antiplatelet therapy (DAPT) by age in patients undergoing percutaneous coronary intervention (PCI) are limited. This study assessed clinical outcomes based on age groups and DAPT duration, focusing on patients aged ≥75 years.

Methods

We analyzed data from 10,487 patients across 5 Korean randomized trials examining the impact of DAPT durations on clinical outcomes after drug-eluting stent implantation. Patients were categorized into 2 groups: ≥75 years (n=1,571) and <75 years (n=8,916). Each group was further stratified into short-term DAPT (1-6 months) and standard DAPT (12 months). The primary outcome was major bleeding within 12 months of PCI. Major adverse cardiovascular and cerebrovascular events (MACCE) and

SUBMITTER: Jin IT 

PROVIDER: S-EPMC12705250 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature