Association of Weight Loss Composition Following Metabolic-Bariatric Surgery With Incident Major Adverse Cardiovascular Events and All-Cause Mortality.

ABSTRACT: Severe obesity is associated with an increased cardiovascular risk. Metabolic-bariatric surgery (MBS) can reduce the risk of cardiovascular events and mortality, potentially depending on weight loss composition. This study assessed the association between post-MBS weight loss composition and major adverse cardiovascular events (MACE) and all-cause mortality. This retrospective, single-center study included patients who underwent MBS between 2012 and 2020. Twelve-month total weight loss (TWL), fat mass loss (FML), fat-free mass loss (FFML), and proportion of FFML within weight loss (FFML/WL) were assessed. The primary endpoint was a composite of MACE and all-cause mortality. The event rate was compared across weight composition tertiles, while adjusting for cardiometabolic medication, age,

SUBMITTER: Nuijten MAH 

PROVIDER: S-EPMC12705300 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature