Tertiary lymphoid structure-related RNA indicator as metastasis risk factor in nasopharyngeal carcinoma.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) patients who develop distant metastasis have significantly reduced survival rates. Therefore, understanding of metastasis and identifying high-risk patients are important, and a robust predictive model for accurately assessing the distant-metastasis risk before treatment is needed for personalised treatment.

Methods

NPC patients diagnosed at four Hong Kong public hospitals and at Sun Yat-Sen University Cancer Center in Guangzhou were selected. Patients were divided into two training cohorts (n = 77 and 30, respectively) and one testing cohort (n = 70). Two independent NPC cohorts collected from Sun Yat-Sen University Cancer Center (n = 88), and a randomised phase III trial (NPC-0501) in Hong Kong (n = 81) were used for external valid

SUBMITTER: Hou Z 

PROVIDER: S-EPMC12705341 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature