The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity.

ABSTRACT: Innate immune memory, also called trained immunity, refers to the ability of innate immune cells to gain memory characteristics after transient stimulation, resulting in a nonspecific modified inflammatory response upon secondary remote challenge. Bronchial epithelial cells (BECs) participate in innate immune defence and are the first cells of the lower respiratory tract to encounter inhaled pathogens. We recently showed that BECs are capable of innate immune memory after preexposure to Pseudomonas aeruginosa flagellin through epigenetic mechanisms. In the present study, we investigated such mechanisms through the modification of chromatin architecture induced by flagellin preexposure that results in subsequent changes of gene expression. By conducting an unsupervised approach to jointly a

SUBMITTER: Bigot J 

PROVIDER: S-EPMC12705438 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature