CD99 is a potential diagnostic and immunological biomarker in pan-cancer.

ABSTRACT:

Background

As a cell adhesion factor, cluster of differentiation 99 (CD99) mainly plays a role in regulating cell differentiation. In cancer research, CD99 primarily focuses on sarcoma. Recent studies have revealed that CD99 plays a critical role in the initiation and progression of several cancers. However, a comprehensive pan-cancer analysis of CD99 has not been performed.

Methods

In this study, we utilized advanced bioinformatics techniques to conduct an in-depth investigation of CD99 expression across diverse tumors, its prognostic and diagnostic implications, the predominant modes of genetic alteration, correlations with immune cell infiltration and immune checkpoints, enrichment analyses of related gene expression, and mechanisms of drug resistance.

Results

Our

SUBMITTER: Jiang J 

PROVIDER: S-EPMC12705483 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature