Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation.

ABSTRACT:

Background

Cardiac arrest (CA) remains a leading cause of mortality and long-term neurological disability. In cases of refractory CA, extracorporeal cardiopulmonary resuscitation (ECPR) may be implemented as a salvage therapy to mitigate hypoxic-ischemic brain injury and improve outcomes. However, the optimal target temperature in the specific context of ECPR remains uncertain. The objective of this study was to evaluate the impact of hypothermia on brain function using a controlled experimental model of ECPR.

Methods

Twelve pigs were subjected to 5 min of untreated ventricular fibrillation, followed by 25 min of conventional cardiopulmonary resuscitation (CPR). At 30 min, veno-arterial extracorporeal membrane oxygenation support was initiated, and defibrillation attempts we

SUBMITTER: Moreau A 

PROVIDER: S-EPMC12705496 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature