Dual-Omics Mapping of Tinnitus Phenotype Transition in Noise-Exposed Auditory Cortex.

ABSTRACT: Noise-induced hearing loss (NIHL) is a primary contributor to tinnitus, involving mechanisms such as inflammatory damage, central sensitization, and auditory cortex remodeling. However, not all cases of tinnitus are accompanied by NIHL, and the precise relationship between the two remains incompletely understood. Phosphorylation/dephosphorylation, as a core mechanism for fine cellular regulation, influences neuronal excitability, immune responses, and disease development by modulating protein activity, signal transduction, and gene expression. We hypothesized that aberrant phosphorylation levels may alter auditory cortex neuron function, leading to pathological changes at the protein level. Leveraging auditory cortex tissue from a noise-induced tinnitus model, we systematically investigate

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12705524 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature