Identification and validation of prognostic genes and prognostic models associated with cutaneous melanoma and integrative stress response.

ABSTRACT:

Background

Skin cutaneous melanoma (SKCM) is a highly invasive cancer with dismal prognosis. Integrated stress response (ISR) is associated with tumorigenesis and progression, but its relationship with SKCM prognosis is unclear. This research aimed to identify relevant prognostic genes for SKCM prognosis and treatment insights.

Methods

Data were obtained from public databases. Differential expression and regression analyses were used to identify prognostic genes. Based on these genes and independent prognostic factors, risk models and nomograms were constructed to assess their clinical application potential in SKCM. Then, immune microenvironment changes in SKCM were explored according to risk-group grouping, providing a basis for stratified treatment decisions for SKCM patie

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12705592 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature