Serum periostin as a novel biomarker and therapeutic target in coronary heart disease.

ABSTRACT:

Background

Coronary artery disease (CAD) remains a significant global contributor to morbidity and mortality, necessitating a deeper understanding of its molecular mechanisms. This study aimed to identify and analyze differentially expressed genes associated with CAD, assess their functional enrichment, and construct protein-protein interaction (PPI) networks to elucidate the molecular mechanisms underlying the disease.

Methods

Data integration from two Gene Expression Omnibus datasets (GSE66360 and GSE42148) was performed using bioinformatics tools, with batch effects corrected via the R package sva. Differential gene expression analysis was conducted using the limma package in R, enabling identification of genes with statistically significant expression differences between

SUBMITTER: Su Q 

PROVIDER: S-EPMC12705617 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature