Genetic diversity and evolutionary adaptation of Clostridium paraputrificum, a rare pathogen in humans.

ABSTRACT: Clostridium paraputrificum infection in humans is extremely rare, and its pathogenesis and evolutionary mechanisms remain poorly understood. We sequenced the genome of strain CP_SH01 isolated from the blood culture of an ICU patient with acute abdominal injury and bloodstream infection. The genome harbored an intact prophage and ten insertion-sequence elements. Genome-wide metabolic reconstruction uncovered 42 fully complete modules linked to the utilization of different sugars and fermentation. Phylogenomic analysis of 42 global strains revealed two clades with substantial genetic diversity. A comparative genomic analysis was carried out to decode the pangenomic structure of C. paraputrificum, and functional differences between 2,434 core genes and 5,939 accessory genes. Meanwhile, 52 gen

SUBMITTER: Liu J 

PROVIDER: S-EPMC12705670 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature