Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus.

ABSTRACT: Iron transporters are essential for numerous iron-dependent biological processes. Among them, SLC22A17 plays a key role in lipocalin-2 (LCN2)-mediated iron transport and is implicated in several human diseases. However, its precise molecular and physiological functions remain poorly understood. In this study, we demonstrate that Slc22a17 is critical for postnatal neurogenesis through its regulation of iron homeostasis in the hippocampus. Conditional knockout of Slc22a17 in the murine brain results in early postnatal mortality, severe growth retardation, excessive neural stem cell (NSC) apoptosis, and cognitive impairments, all driven by oxidative stress caused by iron overload. Mechanistically, using TurboID-based proximity labeling and immunoprecipitation, we identify an interaction betwe

SUBMITTER: Tao L 

PROVIDER: S-EPMC12705704 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature