Association between hysterectomy, oophorectomy, and risk of breast cancer: a meta-analysis.

ABSTRACT:

Objectives

This meta-analysis seeks to clarify the relationship between hysterectomy, oophorectomy, and the subsequent risk of developing breast cancer.

Methods

A comprehensive literature search was conducted across PubMed, the Cochrane Library, and Embase to identify relevant studies. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). Statistical analyses were performed using Stata software (version 14.0), with hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) calculated. Publication bias was assessed using funnel plots and Egger's test.

Results

A total of 12 studies were included, comprising 9 cohort studies and 3 case-control studies, with publication years ranging from 1988 to 2023, involving 5,868,660

SUBMITTER: Wang B 

PROVIDER: S-EPMC12705852 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature