Loss of the miR-221/222 Cluster Promotes the Pathogenesis of Osteoarthritis in Inflamed Mouse Chondrocytes and Osteoarthritis Models.

ABSTRACT: Osteoarthritis (OA) is a degenerative joint disorder with the destruction of the joint's structural and functional which affects the entire joint. An important feature of OA is the progressive degeneration of articular cartilage due to an imbalance between extracellular matrix synthesis and degradation. While the molecular basis of OA remains unclear, microRNAs (miRNAs) have been recognized as key factors in controlling cartilage homeostasis and inflammation. Of these, miR-221 and miR-222 are implicated in inflammatory and degenerative disease, but their exact role in OA has yet to be determined. This study aims to assess the impact of miR-221/222 cluster knockout (KO) on mouse OA models and to explore its underlying mechanisms. OA was induced in miR-221/222 KO mice utilizing the destabili

SUBMITTER: Liu X 

PROVIDER: S-EPMC12705854 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature