Placental MRI texture features in prenatal exposure to opioids and tobacco.

ABSTRACT: Opioid use disorder during pregnancy significantly increases the likelihood of adverse developmental outcomes in the offspring. Texture analysis serves as a quantitative technique that could be vital in identifying microstructural variations in placentas that have been exposed to opioids and other substances. This is a prospective, multisite cross-sectional study that recruited pregnant women that were greater than 16 weeks of gestation. We manually segmented placenta tissue from half-Fourier single-shot turbo spin-echo (HASTE) sequence MR images. We then assessed placental surface area and texture features using a radiomics pipeline. Using linear models, we assessed the association of substance use on placental surface area and texture features, accounting for demographic characteristics.

SUBMITTER: Class JA 

PROVIDER: S-EPMC12706000 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature