ASS1 facilitates T-ALL progression via the arginine-mediated mTORC1/c-Myc signaling pathway.

ABSTRACT: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy arising from abnormal T-cell differentiation. Conventional treatment strategies remain suboptimal, and no effective targeted therapy is currently available. Here, we found that ASS1 is significantly upregulated in T-ALL and is associated with poor prognosis. Inhibition of ASS1 expression markedly suppresses T-ALL progression both in vitro and in vivo. Mechanistically, RNA-seq revealed that ASS1 depletion led to a significant downregulation of one-carbon metabolism and ribose synthesis pathways, and the mTORC1/c-Myc signaling pathway. Experimental validation confirmed that mTORC1/c-Myc signaling was significantly downregulated upon ASS1 blockage. Furthermore, the intracellular arginine level was significantl

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12706054 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature