Tumor Necrosis Factor Inhibitor Therapy Increases Absolute Lymphocyte Count and Is Associated With Lower Mortality in Patients With Psoriatic Arthritis.

ABSTRACT:

Objective

Pathogenic inflammation in psoriatic arthritis (PsA) includes tumor necrosis factor (TNF) signaling. We observed that lower absolute lymphocyte count (ALC) was associated with greater mortality in persons with rheumatoid arthritis, and the start of TNF inhibitor (TNFi) therapy was associated with increased ALC. The effect of TNFi on ALC and mortality in PsA is not known.

Methods

Using the VA Corporate Data Warehouse, we identified patients with PsA that initiated TNFi in 2010 through 2015 with laboratory tests before and 3 to 24 months after therapy initiation. Patients with PsA seen in rheumatology clinics were matched by age, sex, race and ethnicity with controls. In a subset of local patients and controls, we evaluated markers of inflammation and other correlate

SUBMITTER: Kostadinova L 

PROVIDER: S-EPMC12706118 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature