Cerebral metabolic covariance in delirium: pattern response to symptomatic changes.

ABSTRACT:

Background

Delirium is an acute neuropsychiatric condition linked to increased dementia risk, yet its mechanisms remain unclear. Previous studies reported cerebral hypometabolism. Spatial covariance of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) was applied to acutely unwell inpatients with and without delirium (Delirium, Con_unwell) to derive a delirium-specific metabolic pattern (DP). DP expression was evaluated in healthy older adults (Con_healthy) and patients with delirium superimposed on dementia (DSD) and tracked longitudinally with symptom resolution.

Methods

Seventy participants were included (30 Con_healthy, 10 Con_unwell, 13 Delirium, 17 DSD). Voxel principal components (PCs) identified interco

SUBMITTER: Colloby SJ 

PROVIDER: S-EPMC12706124 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature