Pulmonary Sequelae of Severe Acute COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Dutch Children.

ABSTRACT:

Background

Although rare, COVID-19 in children may lead to hospitalization due to severe respiratory symptoms, or a hyperinflammatory state called Multisystem Inflammatory Syndrome in Children (MIS-C). This study examined respiratory morbidity in children 5 to 12 months after hospitalization for MIS-C or COVID-19.

Methods

In this multi-center, prospective cohort study, children (0-17 years) with a history of hospitalization for MIS-C or COVID-19 in Dutch hospitals were invited for follow-up. Visits were scheduled in one of three academic hospitals, to evaluate current clinical status and health-related quality of life (HRQoL), and perform lung function tests and cardiopulmonary exercise testing (CPET).

Results

72 children were included (43 MIS-C, 29 COVID-19), of whom

SUBMITTER: Noij LCE 

PROVIDER: S-EPMC12706180 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature