Effectiveness of antihypertensive drugs for secondary prevention of ischaemic stroke: a nationwide historic cohort study.

ABSTRACT:

Objectives

To evaluate the impact of various antihypertensive drugs on secondary stroke prevention in a real-life setting.

Design

Nationwide historic cohort study.

Setting

French healthcare system data (SNDS).

Participants

Adults hospitalised for ischaemic stroke between 2014 and 2015 were followed up until December 2021 and stratified based on the presence of atrial fibrillation (AF).

Outcome measures

Risk of stroke recurrence was assessed using a time-dependent Cox cause-specific model accounting for changes in drug exposure. We also investigated the risk of major adverse cardiovascular events (MACE) or all-cause death. Models were adjusted on stroke characteristics, coprescriptions and co-morbidities, at inclusion and across follow-up.

Results

SUBMITTER: Perrier J 

PROVIDER: S-EPMC12706251 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature