The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop.

ABSTRACT: Animal longevity is a function of global vital organ functionality and, consequently, a complex polygenic trait. Yet, monogenic regulators controlling overall or organ-specific ageing exist, owing their conservation to their function in growth and development. Here, by using pathway analysis combined with wet-biology methods on several dynamic timelines, we identified Hnf1a as a novel master regulator of the maturation and ageing in the adult pancreatic islet during the first year of life. Conditional transgenic mice bearing suboptimal levels of this transcription factor in the pancreatic islets displayed age-dependent changes, with a profile echoing precocious maturation. Additionally, the comparative pathway analysis revealed a link between Hnf1a age-dependent regulation and immune signa

SUBMITTER: Mathisen AF 

PROVIDER: S-EPMC12706456 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature