The effects of house dust-derived mixtures of organophosphate esters on Leydig cell phenotype, function, and lipidome†.

ABSTRACT: Organophosphate esters (OPEs), widely used as flame retardants and plasticizers, are frequently detected in indoor environments and human tissues, raising concerns about their potential endocrine-disrupting effects. In this study, we examined the effects of a household dust-based mixture of OPEs, along with two structural distinct sub-mixtures, on the phenotype, function, and lipidome on MA10 Leydig cells. Using high-content imaging, we identified increase in oxidative stress levels and accumulation of lipid droplets as common phenotypic effects across mixtures. Notably, the triaryl OPE sub-mixture exhibited greater potency, suggesting that specific structural features contribute to the toxicity of OPEs. While the OPE mixture did not impair basal steroid hormone production in MA-10 cells,

SUBMITTER: Li Z 

PROVIDER: S-EPMC12706469 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature