A Cross-Sectional Analysis of Social Determinants of Health in Bipolar Disorder: Exploring Gender-Related Differences.

ABSTRACT:

Objectives

To explore the clinical impact of social determinants of health (SDoH) stress in bipolar disorder (BD) course of illness and to explore potential gender differences in SDoH stress endorsement.

Methods

2280 individuals living with BD type I or II (62% women; 67.5% BD-I) participating in the Mayo Clinic Bipolar Biobank who completed a questionnaire assessing positive and negative-valent stressors in the 12 months prior to study enrollment were included for this analysis. Six negative stressors were used as proxies of SDoH. Generalized linear models were used to test the association between SDoH stressors and markers of illness severity as well as potential differences by sex by including an interaction term.

Results

After adjusting for age, sex, and recruitme

SUBMITTER: Gardea-Resendez M 

PROVIDER: S-EPMC12706543 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature