Feasibility of Treating Eosinophilic Chronic Rhinosinusitis Using Short-Chain Fatty Acids.

ABSTRACT:

Objective

Epithelial cell-derived cytokines play a key role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNPs). Short-chain fatty acids (SCFAs) are carboxylic acids with 1-6 carbon atoms that are produced by the microbiota, which play a significant role in inflammation. We evaluated the potential role of SCFAs in eosinophilic chronic rhinosinusitis (ECRS).

Methods

Gene expression levels of G protein-coupled receptor 41/free fatty acid receptor 3 (GPR41/FFAR3), GPR43/FFAR2, thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33 in nasal polyp (NP) tissues were analyzed using quantitative real-time polymerase chain reaction. Primary normal human bronchial epithelial (NHBE) cells were stimulated with polyinosinic-polycytidylic acid (poly(I:C)

SUBMITTER: Gozawa R 

PROVIDER: S-EPMC12706560 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature