Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors.

ABSTRACT: Sex differences in alcohol use behaviors are well-established: males typically engage in heavier and more frequent drinking and exhibit more externalizing behaviors (e.g., other substance use), while females often transition to dependence more rapidly and present more internalizing psychopathology (e.g., depression). The biological mechanisms underpinning these differences are relatively unknown. In this study, we investigated the sex-differentiated genetic architecture of 11 alcohol use phenotypes pertaining to frequency, quantity and problematic use by leveraging sex-stratified genome-wide association studies (Ns 40,335 to 613,148). Specifically, we compared SNP-based heritability ( h ² _SNP ) estimates, individual genetic

SUBMITTER: Vilar-Ribo L 

PROVIDER: S-EPMC12706599 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature