The impact of anticholinergic burden on the development of mild behavioral impairment.

ABSTRACT:

Objective

Mild Behavioral Impairment (MBI) is a syndrome of late-life-onset persistent neuropsychiatric symptoms. Anticholinergic medication is commonly prescribed in older adults. Both MBI and anticholinergic exposure are associated with increased dementia risk. We sought to understand the association of anticholinergic burden (ACB) with MBI.

Design setting participants

We mapped ratings on the Neuropsychiatric Inventory Questionnaire to the MBI checklist (MBI-C) using an established algorithm to define MBI status in cognitively unimpaired individuals in the National Alzheimer's Coordinating Center database. We then assessed the association between time-varying ACB ratings and risk of incident MBI.

Results

4865 participants met inclusion criteria and were followed fo

SUBMITTER: Franklin CE 

PROVIDER: S-EPMC12706612 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature