Preserved cognitive-functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project.

ABSTRACT:

Introduction

Research on dementia in centenarians is scarce. This study assesses the 2024 Lancet Commission risk factors for dementia in Colombian centenarians.

Methods

The Clinical Dementia Rating-Sum of Boxes (CDR-SB), Mini-Mental State Examination, and Barthel Index were evaluated in Colombian centenarians. A preserved cognitive-functional phenotype (PCFP), defined by a CDR-SB <2 and a Barthel index ≥60, was utilized to signify the absence of dementia based on cognitive screening instruments. Associations with age-related clinical variables were assessed through multivariate analyses.

Results

Among 160 centenarians, 63.7% did not meet the PCFP criteria and were classified as having dementia. Frailty, alcohol intake, and depression were linked to dementia, while phy

SUBMITTER: Lozada-Martinez ID 

PROVIDER: S-EPMC12706638 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature