Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson's disease patients.

ABSTRACT:

Background

Postural instability/gait difficulty (PIGD) subtype in Parkinson's disease (PD) portends poorer prognosis and limited treatment response. While cerebral small vessel disease (CSVD) is implicated in motor impairment, its specific association with PIGD remains underexplored. This study aims to investigate the correlation between the severity of CSVD and PIGD subtype in PD patients.

Methods

This cross-sectional study enrolled 161 PD patients (mean age 71.14 ± 7.04 years). Motor subtyping [postural instability and gait difficulty (PIGD)/tremor-dominant (TD)/intermediate type (IT)] used MDS-UPDRS-derived ratios. CSVD burden was quantified via two validated MRI-based scores: the total CSVD burden score (range 0-4) and modified CSVD burden score (range 0-6). Multivariate

SUBMITTER: Ge Y 

PROVIDER: S-EPMC12706657 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature