Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch.

ABSTRACT:

Importance

Even within individuals who are amyloid positive, clinical symptoms can be impacted by Alzheimer pathology, other pathologic proteins, and cognitive reserve or resilience. Understanding how each of these factors contributes to a patient's clinical presentation is crucial for prognosis and treatment decisions in the era of disease-modifying therapies.

Objective

To evaluate tau-clinical mismatch as a means to identify those more likely to harbor copathology and/or exhibit resilience to Alzheimer pathology.

Design, setting, and participants

This was a longitudinal, observational cohort study conducted from 2004 to 2024. The setting included multiple academic medical centers in the US participating in the Alzheimer's Disease Neuroimaging Initiative (ADNI) or Pe

SUBMITTER: Brown CA 

PROVIDER: S-EPMC12706664 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature