Microfluidic Thread-Based Analytical Platform for Reaction Screening Enabled by In Situ Thread Spray Mass Spectrometry.

ABSTRACT: This study describes a microfluidic thread-based analytical device (μTAD) capable of in situ mass spectrometric analysis for continuous flow reaction monitoring. Organic reaction screening is foundational to drug discovery. Microfluidic devices are of special interest here because they provide continuous reaction monitoring with advantages such as the use of smaller reagent volumes and short analysis times. We created a μTAD platform from cellulose thread and a microscope glass slide in a Y-shaped format, which enabled multiple reactants to be introduced through individual channels/reservoirs. The naturally corrugated and intertwined subfibers within cellulose thread substrates serve as serpentine mixing medium, requiring no special preparation. The capillary action behind the flow of the

SUBMITTER: Wairegi SG 

PROVIDER: S-EPMC12706755 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature