Association of metabolic syndrome and hyperuricemia with mortality in patients with chronic kidney disease: a UK biobank study.

ABSTRACT:

Background

Chronic kidney disease (CKD) has detrimental effects on health through multiple pathophysiological mechanisms, significantly reducing life expectancy and contributing to a substantial disease burden. Therefore, this study aims to explore the association of metabolic syndrome (MetS) and hyperuricemia (HUA) with all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD).

Methods

Overall, 28,278 patients with CKD, defined by estimated glomerular filtration rate < 60 mL/min/1.73 m² or urine albumin creatinine ratio > 3 mg/mmol, MetS (≥ 3 of 5 criteria), and HUA (> 7.0 mg/dL in males, > 6.0 mg/dL in females) were assessed. The outcomes included all-cause and cardiovascular mortality. Associations were assessed using multivariate-adj

SUBMITTER: Wu C 

PROVIDER: S-EPMC12706888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature