Transcriptome profiling of peripheral blood mononuclear cells from highly susceptible adult cattle infected with a virulent strain of Babesia bovis.

ABSTRACT:

Background

Bovine babesiosis is a tick-borne disease that poses a significant economic threat to cattle industries in tropical and subtropical areas, and Babesia bovis is the most virulent causative agent of bovine babesiosis. This apicomplexan parasite infects erythrocytes of cattle, causing severe hemolytic disease, and animals that survive an acute infection become persistently infected for life. Adult cattle (> 1 year of age) are highly susceptible and often succumb to acute infection. Protective host immunity involves peripheral blood mononuclear cells (PBMCs) including monocytes, dendritic cells (DC), natural killer (NK), T cells, and B cells, all of which act to control the pathogen. Monocytes release the cytokines interleukin (IL)-1β and tumor necrosis factor (TNF) and nitr

SUBMITTER: Capelli-Peixoto J 

PROVIDER: S-EPMC12706890 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature