Stage- and sex-specific associations of prenatal individual and mixed metals exposure with adiposity peak and adiposity rebound among children: a prospective birth cohort study.

ABSTRACT:

Background

Adiposity peak (AP) and adiposity rebound (AR) are key indicators of early childhood growth, which are closely related to obesity, premature puberty, and metabolic abnormalities. Epidemiological studies have shown that prenatal metal exposure is linked to obesity in children. However, studies concerning the association of metals during pregnancy with AP and AR in children are scarce.

Methods

We measured the concentration of 17 serum metal elements including aluminum (Al), vanadium, manganese (Mn), iron, cobalt (Co), nickel, copper, zinc, selenium, cadmium, barium (Ba), thallium (Tl), lead, calcium, magnesium, mercury (Hg), and molybdenum across three trimesters and in cord blood from 2718 mother-infant dyads. Individual body mass index (BMI) trajectories from birt

SUBMITTER: Zuo Y 

PROVIDER: S-EPMC12706989 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature