Jiawei Buyang Huanwu Decoction modulates gut microbiota and metabolic profiles in a rat model of idiopathic pulmonary fibrosis.

ABSTRACT:

Introduction

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with irreversible fibrosis and poor prognosis. Jiawei Buyang Huanwu Decoction (JBHD) has demonstrated therapeutic effects, but the exact mechanisms, particularly those mediated by the gut microbiota, remain largely unexplored. This study aimed to explore how JBHD modulates gut microbiota, and how these changes may influence host metabolic regulation in the context of IPF.

Methods

The IPF model was established via intratracheal bleomycin injection. After 28 days of treatment, feces samples were obtained for 16S rRNA gene sequencing, whereas serum and urine samples were collected for metabolomic analyses.

Results

Gut microbiota analysis showed that JBHD restored microbial dysbiosis in IPF rat

SUBMITTER: Sun D 

PROVIDER: S-EPMC12707051 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature