Critical shift phase in deep vein thrombosis development after major sellar region tumor surgeries: a systematic review.

ABSTRACT:

Background

Sellar region tumors, such as craniopharyngiomas, pituitary adenomas, and chordomas, pose substantial surgical complexity. Although outcomes have improved, venous thromboembolism (VTE), particularly deep vein thrombosis (DVT), remains a significant postoperative risk. While prior studies report elevated VTE incidence in neurosurgery, the specific mechanisms and timing of peak vulnerability after sellar tumor surgery are not well established.

Objective

This study aims to identify the critical shift phase of heightened DVT risk after major sellar region tumor resections and to elucidate the pathophysiologic role of perioperative neuroendocrine disturbances in inducing a hypercoagulable state.

Methods

A systematic review was performed according to PRISMA guide

SUBMITTER: Wardhana DPW 

PROVIDER: S-EPMC12707076 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature