The GPCR NMUR-1 mediates neural regulation of energy homeostasis in response to pathogen infection.

ABSTRACT: A key challenge in immunology is understanding how the innate immune system achieves specificity against diverse pathogens. Our previous work in Caenorhabditis elegans identified NMUR-1, a neuronal G protein-coupled receptor homologous to mammalian neuromedin U receptors, as a regulator of pathogen-specific innate immune responses. Here, we used quantitative proteomics and functional analyses to show that NMUR-1 modulates the expression of mitochondrial F₁F_O ATP synthase subunits and regulates ATP levels during infection, linking neuronal signaling to host energy metabolism. Loss of NMUR-1 leads to reduced ATP and reactive oxygen species (ROS) concentrations in infected animals, altering survival outcomes in a pathogen-specific manner. We further demonstrate th

SUBMITTER: Wibisono P 

PROVIDER: S-EPMC12707106 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature