CpoS-Inc interactions facilitate host cell modulation during <i>Chlamydia trachomatis</i> infection.

ABSTRACT:  Chlamydia trachomatis (C.t.), the leading bacterial cause of sexually transmitted infections, replicates within a unique intracellular compartment called the inclusion, which is modified by secreted proteins known as inclusion membrane (Inc) proteins. Here, we further characterize CpoS, an Inc protein previously shown to be critical for bacterial replication and inclusion development. We demonstrate that CpoS directly binds multiple coiled-coil region-containing Incs and engages Rab GTPases at a separate site. Notably, CpoS-InaC interactions facilitate the recruitment of select Arf GTPases to the inclusion membrane, while Rab recruitment occurs independently of these interactions. Biochemical and biophysical analyses revealed that Incs self-oligomerize to form higher-

SUBMITTER: Tijerina X 

PROVIDER: S-EPMC12707108 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature