VAR2CSA-reactive IgG in Brazilian women exposed to <i>Plasmodium falciparum</i> or <i>P. vivax</i> infection during pregnancy.

ABSTRACT: Placental malaria (PM) causes mortality and severe morbidity in areas with stable Plasmodium falciparum transmission. The selective placental accumulation of P. falciparum-infected erythrocytes (IEs) is mediated by VAR2CSA, a PfEMP1-type parasite ligand that binds exclusively to placenta-restricted CSA. VAR2CSA-specific IgG is therefore generally restricted to women exposed to P. falciparum infection during pregnancy. However, widespread acquisition of VAR2CSA-reactive IgG outside pregnancy among Colombian and Brazilian individuals has been reported, supposedly due to cross-reactivity between VAR2CSA and the P. vivax-specific antigen PvDBP. Here, we measured levels and Fc-afucosylation of VAR2CSA-reactive IgG in plasma from pregnant Brazilian women at delivery,

SUBMITTER: Dos Santos MI 

PROVIDER: S-EPMC12707141 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature