Immune System Alterations in Depression across Baseline and Flu Vaccine Challenge.

ABSTRACT: There are multiple reports of elevated inflammation in patients with major depression. It is, however, unclear whether these reported perturbations in immune functions in depression affect the general functionality of the peripheral immune system. Here, using single-cell RNA-sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) extracted from blood samples collected prior to a flu vaccination administration/immunization (at baseline), we found downregulated T cell and B-cell-associated gene expression repertoire coupled with a selectively upregulated plasmablast, CD14 classical monocytes, and natural killer (NK) proliferating cell-associated gene expression in 9 depressed patients (6 females) compared to 5 healthy controls (5 females), as well as in association with depressi

SUBMITTER: Arasappan D 

PROVIDER: S-EPMC12707279 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature