A model of transcriptional bursting dynamics based on coupling between chromatin and enhancer states.

ABSTRACT: In recent years, it has become evident that transcription is not always a continuous process. Rather, many genes exhibit bursting behavior characterized by discrete periods of transcriptional activity and inactivity. While transcriptional bursting has been broadly observed across different organisms, from bacteria to mammals, we lack a mechanistic understanding of the molecular events that regulate this widespread process. Specifically, how the expression of a 'bursty' gene is quantitatively determined by different molecular factors such as the concentration of transcription factors (TF) and architecture of the enhancers is not well understood. Here, we introduce a model based on the interplay between chromatin state and TF binding in order to describe bursting dynamics. We leverage the wi

SUBMITTER: Axelrod O 

PROVIDER: S-EPMC12707286 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature