Aqueous Humor Exosomal Membrane Proteins: Decoding Pathogenic Molecular Signatures in Retinitis Pigmentosa.

ABSTRACT:

Purpose

To establish a cell origin tracing framework for aqueous humor (AH) exosomal membrane proteins and decipher their pathological implications in retinitis pigmentosa (RP).

Methods

In this prospective cohort study, comprehensive ophthalmic evaluations were conducted in 14 patients with RP with concurrent cataracts and 7 age-matched senile cataract controls. AH samples from these cohorts underwent exosomal membrane protein profiling via EVArray technology. Integrated bioinformatics analysis incorporated single-cell RNA sequencing data sets from human ocular tissues. Gene Ontology (GO) enrichment analysis with cellular trajectory mapping was performed to elucidate disease-associated pathways.

Results

Patients with RP in this cohort predominantly exhibited character

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC12707327 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature