Hemi-Indigiosin: A pH and Red-Light Responsive Transmembrane HCl Transporter.

ABSTRACT: Synthetic anion transporters have emerged as promising therapeutic agents. However, their targeting ability is still low. Herein, we present hemi-indigiosin, which is structurally related to prodigiosin-a well-studied natural product exhibiting a wide range of biological activities. Our hemi-indigiosin is shown to have similar HCl transport selectivity and pH-dependent activity as prodigiosin, while in addition it can be deactivated by irradiation with visible light. This deactivation is effective due to high photoconversion from the active chloride-binding Z-isomer to the inactive E-isomer, not exposing a chloride-binding site. Transport activity is thus controlled by both pH change and light, which will allow improved targeting of pathological sites and prevent ecological impact after dr

SUBMITTER: Duindam N 

PROVIDER: S-EPMC12707358 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature