New naphthalene-containing enamides: synthesis, structural insights and biological screening as potential anticancer agents against Huh-7 cancer cell line.

ABSTRACT: Naphthalene and enamide derivatives are prevalent intracellular tubulin assembly inhibitors, and their optimization is critical for the creation of targeted anticancer agents. A number of new compounds containing naphthalen-1-yloxy and enamide functions connected through N'-acetoxyhydrazide linker were designed and synthesized and their biological activity were tested as possible anticancer agents. The cytotoxic activity of the constructed naphthalene-enamide analogs was studied on Huh-7 hepatocellular carcinoma cell line. The analogs 5f and 5g with 4-methylbenzene and 4-methoxybenzene in the 3,4,5-trimethoxyenamide moiety were proved to have outstanding cytotoxic activity with superior cytotoxic action (IC₅₀ = 2.62 and 3.37 µM, respectively) toward the growth of Huh-7 ce

SUBMITTER: Saleem RM 

PROVIDER: S-EPMC12707369 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature