Elevated plasma CXCL9 and CHI3L1 prior to HCT predict post-HCT lung complications in children.

ABSTRACT:

Objectives

Lung complications occur commonly post-haematopoietic stem cell transplant (HCT) in children and contribute significantly to mortality. The development of biomarkers predictive of post-HCT lung complications may improve outcomes for these children. Therefore, the primary objective of this study was to identify pre-transplant plasma biomarkers predictive of lung complications in children undergoing HCT.

Methods

Plasma samples from 117 pre-HCT patients were used to measure 78 soluble immune analytes, and extensive clinical metadata were retrospectively collected from the electronic medical record, including clinical characteristics of the post-HCT lung complications.

Results

Firstly, we showed that the plasma cytokine signature of children undergoing HCT diff

SUBMITTER: Walker H 

PROVIDER: S-EPMC12707545 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature