Comprehensive analysis of genes associated with necroptosis and pyroptosis in intestinal ischemia-reperfusion injury.

ABSTRACT:

Background

Intestinal ischemia-reperfusion (II/R) injury is a severe clinical condition in which regulated cell death programs-including pyroptosis and necroptosis-have emerged as key drivers of tissue damage and inflammation. We sought to delineate cell-death-related molecular signatures and candidate therapeutic targets in II/R injury.

Methods

We obtained transcriptome datasets from Gene Expression Omnibus (GEO) databases for mice (GSE96733, GSE232246) and humans (GSE37013). We cross-referenced genes associated with necroptosis and pyroptosis with differentially expressed genes to identify death-related features. Hub genes were identified through the topological structure of protein interaction networks and validated using an internal validation set, an independent validat

SUBMITTER: Bao S 

PROVIDER: S-EPMC12707633 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature