Anatomical considerations in acromegalic patients: A multicentric cohort study.

ABSTRACT:

Background

Changes in craniofacial morphology due to elevated levels of growth hormone (GH) vary according to ethnic groups studied in the international literature. We aimed to evaluate the radiologic and endoscopic anatomical variations in acromegalic patients, in comparison with non-functioning pituitary adenomas (NFPA) in the Mexican population.

Methods

One hundred and fifteen patients with endocrinologically and histologically confirmed diagnosis of GH-secreting pituitary adenoma (PA) and NFPA, treated only by endoscopic endonasal approach, in ten different institutions in Mexico, were studied over a 1-year period. Hormonal levels of GH, somatomedin, preoperative neuroimaging, and intraoperative endoscopy were analyzed to evaluate morphological changes specific to the Me

SUBMITTER: Escamilla-Chavez E 

PROVIDER: S-EPMC12707724 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature