Strikingly different neurotransmitter release strategies in dopaminergic subclasses.

ABSTRACT: Neuronal function is intimately tied to axodendritic polarity. Neurotransmitter release, for example, is usually the role of the axon. There are widespread exceptions to this rule, however, including many mammalian neuronal types that can release neurotransmitter from their dendrites. In the mouse olfactory bulb, closely related subclasses of dopaminergic interneuron differ markedly in their polarity, with one subtype lacking an axon entirely. These axon-bearing and anaxonic dopaminergic subclasses have distinct developmental profiles and sensory responses, but how their fundamental polarity differences translate to functional outputs remains entirely unknown. Here, we provide anatomical evidence for distinct neurotransmitter release strategies among these closely related dopaminergic subt

SUBMITTER: Dorrego-Rivas A 

PROVIDER: S-EPMC12707814 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature