Impact of Influenza Vaccination during Pregnancy on Maternal Influenza Disease Severity in Rural Nepal.

ABSTRACT: Although maternal influenza vaccination can prevent influenza morbidity and mortality, data are limited on vaccine efficacy/effectiveness against severe disease in low- and middle-income countries (LMICs) at the community level. We evaluated the impact of maternal influenza vaccination on maternal influenza disease severity across seasons in a rural subtropical area in South Asia by analyzing data from a vaccine clinical trial conducted between 2011 and 2014 in Sarlahi District, Nepal. Participants were randomized 1:1 to trivalent seasonal influenza vaccine or saline placebo and followed through 180 days postpartum. Weekly household-based active respiratory surveillance was conducted; if participants reported fever and respiratory symptoms, a midnasal swab was collected and tested for infl

SUBMITTER: Frivold C 

PROVIDER: S-EPMC12707825 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature