Clinical and Neuroimaging Effects of Mindfulness-Based Cognitive Therapy for Symptomatic Obsessive-Compulsive Disorder Patients after First-Line Treatments: A Randomised Controlled Trial.

ABSTRACT:

Introduction

Obsessive-compulsive disorder (OCD) is a chronic condition where many patients remain symptomatic despite first-line treatments such as cognitive behavioural therapy and selective serotonin reuptake inhibitors. This randomised controlled trial evaluated mindfulness-based cognitive therapy (MBCT) efficacy as an augmentation strategy and its impact on brain functional connectivity.

Methods

Sixty-eight participants with moderately symptomatic OCD were randomised into MBCT or treatment as usual (TAU). Clinical outcomes were evaluated using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Obsessive-Compulsive Inventory, alongside other relevant secondary outcomes. Data were analysed using repeated-measures ANOVA to assess time * group effects. Neuroimaging

SUBMITTER: Serra-Blasco M 

PROVIDER: S-EPMC12707885 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature