Differential DNA Methylation in the Benign and Cancerous Prostate Tissue of African American and European American Men.

ABSTRACT:

Background

African American (AA) men are at increased risk of prostate cancer compared with European American (EA) men. Biological mechanisms, including epigenetics, likely contribute to this disparity, but prior studies have been limited by sample size, candidate gene approaches, or lack of epigenome-wide DNA methylation (DNAm) data.

Methods

To improve our understanding of these mechanisms, we compared DNAm features distinguishing tumor and paired histologically benign tissue from 76 AA and 75 EA patients with prostate cancer. We generated genome-wide array-based DNAm data and conducted differential methylation analyses comparing tumor and benign tissues in each ancestry group. We then examined the predictive ability of our identified sites and differential methylation by a

SUBMITTER: Chernoff M 

PROVIDER: S-EPMC12707997 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature